Another great example of MIRA powering next‑gen CRISPR diagnostics. 🧬
The CLUE platform decouples crRNA functions to make Cas12a tuning far more flexible — and with MIRA isothermal amplification behind it, detection wraps up in just 20 minutes.
100% sensitivity and specificity across 120 clinical samples. That's the kind of data that makes you proud of the tech you work with. 🙌
| 🔬 A new breakthrough in CRISPR diagnostics — powered by MIRA.
Traditional CRISPR diagnostics tightly couple crRNA target recognition and cleavage activity. Researchers must redesign crRNA sequences for rate matching — a constrained, trial‑and‑error process.
This work introduces the CLUE platform — decoupling crRNA functions using RNA oligos for independent tuning of Cas12a cis‑cleavage.
Powered by MIRA isothermal amplification:
⚡ Self‑initiated reactions via strand displacement
⏱️ Detection completed in just 20 minutes
🎯 100% sensitivity and specificity for SARS‑CoV‑2 and influenza across 120 clinical samples — matching RT‑qPCR
🧬 A highly customizable universal solution for POCT
This is what happens when MIRA meets smarter CRISPR design — faster, simpler, and more flexible than ever.
|
The CLUE platform decouples crRNA functions to make Cas12a tuning far more flexible — and with MIRA isothermal amplification behind it, detection wraps up in just 20 minutes.
100% sensitivity and specificity across 120 clinical samples. That's the kind of data that makes you proud of the tech you work with. 🙌
Traditional CRISPR diagnostics tightly couple crRNA target recognition and cleavage activity. Researchers must redesign crRNA sequences for rate matching — a constrained, trial‑and‑error process.
This work introduces the CLUE platform — decoupling crRNA functions using RNA oligos for independent tuning of Cas12a cis‑cleavage.
Powered by MIRA isothermal amplification:
⚡ Self‑initiated reactions via strand displacement
⏱️ Detection completed in just 20 minutes
🎯 100% sensitivity and specificity for SARS‑CoV‑2 and influenza across 120 clinical samples — matching RT‑qPCR
🧬 A highly customizable universal solution for POCT
This is what happens when MIRA meets smarter CRISPR design — faster, simpler, and more flexible than ever.